منابع مشابه
ETS transcription factors and prostate cancer: the role of the family prototype ETS-1 (review).
The ETS family of transcription factors is known to play important roles in various biological processes such as development, differentiation, proliferation, apoptosis, migration, tissue remodeling, invasion and angiogenesis in various cell types including B cells, endothelial cells, fibroblasts as well as diverse neoplastic cells. In prostate cancer, recurrent gene fusions involving members of...
متن کاملTranscriptional regulation of CD1D1 by Ets family transcription factors.
CD1 molecules are MHC class I-like glycoproteins specialized in presenting lipid/glycolipid Ags to T cells. The distinct cell-type specific expression of CD1D1 plays an important role in the development and function of NKT cells, a unique subset of immunoregulatory T cells. However, the mechanisms regulating CD1D1 expression are largely unknown. In this study, we have characterized the upstream...
متن کاملETS Transcription Factors in the Tumor Microenvironment
ETS factors are involved in cancer progression through transcriptional regulation of factors mediating cell cycle, cell growth, apoptosis, cell adhesion and migration. The biological processes regulated by ETS factors are important not only in tumor cells, but also in the surrounding cells comprising the tumor microenvironment. Additionally, ETS factors can serve as transcriptional activators a...
متن کاملThe diverse role of the ETS family of transcription factors in cancer.
Oncogenicity potential was a defining characteristic of v-ets, the first of the large family of ETS transcription factors to be cloned. v-ets was discovered as an oncoprotein fusion with gag and myb in the E26 avian erythroblastosis virus (1). There are now more than 25 ETS family members defined by a DNA binding or ETS domain, which is highly conserved among family members, and binds to the co...
متن کاملExpression profiles frame the promoter specificity dilemma of the ETS family of transcription factors.
Sequence-specific DNA binding proteins that function as transcription factors are frequently encoded by gene families. Such proteins display highly conserved DNA binding properties, yet are expected to retain promoter selectivity. In this report we investigate this problem using the ets gene family, a group of metazoan genes whose members regulate cell growth and differentiation and are mutated...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1993
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1993.tb19864.x